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KMID : 0941820160260020163
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Korean Journal of Clinical Pharmacy
2016 Volume.26 No. 2 p.163 ~ p.171
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Effect of Ginseng on Blood Pressure: A Systematic Review and Meta-Analysis
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Ha Hye-Min
Oh Da-Hyun
Chun Pu-Soon
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Abstract
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Objective: A meta-analysis was performed to determine effect of ginseng on blood pressure.
Methods: The databases of PubMed, Embase, Cochrane Library, RISS, DBpia, KISS, and Koreamed were searched for all published studies from inception to January 2016. The following terms were used: “ginseng”, “hypertension”, and “blood pressure”. Using the Review Manager 5, mean differences (MDs) were pooled to measure the effect of ginseng on blood pressure compared to that of placebo.
Results: Eleven randomized controlled trials were included. In this meta-analysis, ginseng treatment significantly lowered systolic blood pressure (SBP) in a dose-independent way (MD: ?1.99, p = 0.04). In subgroup analysis, 8-12 week consumption of ginseng achieved significantly greater reduction in SBP (MD: ?3.14, p = 0.03), while single administration of ginseng failed to show BP-lowering effect. When ingested over 8-12 weeks, ginseng significantly lowered diastolic blood pressure (DBP) (MD: ?1.96, p = 0.03). No significant association was found between ginseng dose and the magnitude of BP-lowering effect. However, a significant positive relationship was observed between baseline SBP level and the magnitude of SBP reduction (r = 0.848, p = 0.033). Such a relationship was not seen in DBP.
Conclusion: Consumption of ginseng for 8-12 weeks achieved significant reductions in SBP and DBP in a dose-independent way. There was a significant positive relationship between baseline SBP level and the magnitude of SBP reduction.
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KEYWORD
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American ginseng, Korean red ginseng, Korean white ginseng, blood pressure, randomized controlled trial
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